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KMID : 0387420080190010029
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 1 p.29 ~ p.42
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An Experimental Study on the Effect of Sinchim on Enhancing of memory in Rat with water maze
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Jung Hee-Sang
Kim Geun-Woo
Koo Byung-Su
Kim Dong-Hyun
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Abstract
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Objectives : This study was performed to examine the effect of Sinchim on enhancing of memory in rat with water maze.
Methods : Experimental animals(white rat) were classfied into normal, control, and aroma sample group. Then, they were injected .-amyloid into control and aroma sample group rat’s brain about to injure its brain. After rat smelt Sinchim about 12days, I did water maze test and anatomized its hippocampus. Sections were cut coronally at 30 .(XI00)
Results: 1. In acquisition test of water maze learning, .-amyloid injured group took more time than normal group to reach the escape platform noticeably and through the session of trial, Sinchim aroma sample group shortened time than .l3-amyloid injured group after 6 days. 2. In the acetyltransferase(AchE) immunostained method, it was shown that Sinchim aroma sample recovered tbe syntbesis of ChAT(Choloneacetyltransferase).
Conclusion: Smelling Sinchim would be useful for enhancing of memory.
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KEYWORD
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The Effect of Sinchim, Sinchim aroma, water maze
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